Urethral suppositories, also called intraurethral pellet therapy or medicated urethral system for erections (MUSE®), are a self-administered treatment for erectile dysfunction that may be effective for men who dislike penile injections or for whom oral medications are not effective. Alprostadil, a drug used for penile injection therapy, is also available as a small suppository that is placed directly into the urethra to achieve an erection, usually within five to 10 minutes.
Men with mild to moderate kidney or liver disease will need to use lower doses of the PDE5 inhibitors. None of the PDE5 inhibitors are recommended for men with severe kidney disease, those on dialysis, and those with severe liver disease.

There is reliable evidence that oral phosphodiesterase-5 (PDE-5) inhibitors (e.g., sildenafil, vardenafil, tadalafil, mirodenafil, and udenafil) improve erectile functioning in men with ED. However, there is a lack of reliable evidence of the efficacy of hormonal treatments and the value of hormone testing for ED. The American College of Physicians (ACP) developed guidelines on hormonal testing and pharmacological treatments of ED (Qaseem et al, 2009). Current drug therapies include PDE-5 inhibitors as well as hormonal treatment. The ACP recommended clinicians initiate therapy with a PDE-5 inhibitor in men who seek treatment for erectile dysfunction and who do not have a contra-indication to PDE-5 inhibitor use, and clinicians base the choice of a specific PDE-5 inhibitor on the individual preferences of men with erectile dysfunction, including ease of use, cost of medication, and adverse effects profile.
This Indian form of exercise is one of the best alternatives for erectile dysfunction exercises for curing it. if you don’t like doing intense workouts or exercises. Yoga is beneficial in improving blood flow and helps you relax.